COMPANY PROFILE
At TLC we specialize in the custom synthesis of complex organic compounds for use as reference standards by the bio-medical and pharmaceutical industries around the world.
UNCOMPROMISED QUALITY
At TLC, quality is not just a commitment, it is ingrained in our culture. Our extensive COA, which includes HPLC, NMR, MS, IR, EA, GC, Water Content, residual solvents and Assay, coupled with ISO 17034 and ISO 17025 accreditations, serves as a testament to our unwavering dedication to delivering products that meet the highest standards of excellence in the industry.
EXTENSIVE INVENTORY
TLC currently offers over 22,000 certified reference standards from stock and we add approximately 2,000 new standards yearly. Our product line includes Active Pharmaceutical Ingredients (API), drug impurities and metabolite standards, as well as their stable isotope labelled analogues and amino acid/peptide drug standards.
New Stable Isotope-Labeled Reference Standard: Minocycline-d6 Ditrifluoroacetate
We are pleased to announce the successful development of Minocycline-d6 Ditrifluoroacetate, a technically challenging stable isotope-labeled (SIL) reference standard.
Minocycline is a broad-spectrum tetracycline antibiotic widely used in pharmaceutical development and clinical research. This d6-labeled analog is intended to support analytical and bioanalytical studies related to minocycline, including LC-MS/MS method development, validation, and quantitative analysis.
This material has been produced with exceptional quality, offering 99.5% isotopic purity and >98.5% chemical purity in the current batch (COA). The high isotopic purity minimizes isotopic overlap and analytical interference, supporting accurate internal standard performance in LC-MS/MS–based PK and bioanalytical assays. This level of quality helps enable robust, reproducible data generation and supports defensible data packages under GLP conditions, reducing the risk of regulatory questions related to isotopic overlap or analytical interference.
Due to the complexity of synthesis and the challenge of achieving high isotopic purity, this compound is difficult to source at this quality level. Please contact us for availability and a quotation.
New Stable Isotope-Labeled Reference Standard: Minocycline-d6 Ditrifluoroacetate
We are pleased to announce the successful development of Minocycline-d6 Ditrifluoroacetate, a technically challenging stable isotope-labeled (SIL) reference standard.
Minocycline is a broad-spectrum tetracycline antibiotic widely used in pharmaceutical development and clinical research. This d6-labeled analog is intended to support analytical and bioanalytical studies related to minocycline, including LC-MS/MS method development, validation, and quantitative analysis.
This material has been produced with exceptional quality, offering 99.5% isotopic purity and >98.5% chemical purity in the current batch (COA). The high isotopic purity minimizes isotopic overlap and analytical interference, supporting accurate internal standard performance in LC-MS/MS–based PK and bioanalytical assays. This level of quality helps enable robust, reproducible data generation and supports defensible data packages under GLP conditions, reducing the risk of regulatory questions related to isotopic overlap or analytical interference.
Due to the complexity of synthesis and the challenge of achieving high isotopic purity, this compound is difficult to source at this quality level. Please contact us for availability and a quotation.